I am afraid there is no LabTalk access for finding the first empty column from the end, but there is Origin C access, like this
Worksheet wks = Project.ActiveLayer();
int nCols = wks.GetNumCols();
int n1 = wks.FindFirstEmpty(0, true);
wks.DeleteCol(n1, 0, nCols-n1);
We can add this to LT wks method, as it is also available in automation server, so it is simple to add this to LT and thus can be used from Python.
CP