Hi Jon,

If you want to make a histogram for the difference between the i-th cell and (i+1)-th cell, you can do the following: 

1) Make a new column ("Column: Add New Columns" menu, or the corresponding tool button)

2) Highlight the new column, and run Set Column Values tool, and enter 
  the following formula (e.g., when the original column is column B):
 
  abs(col(B)[i+1]-col(B)[i])

3) Make a histogram from this new column ("Plot: Statistics: Histogram" menu).

I hope this is what you are looking for.

--Hideo Fujii
OriginLab