Hi Campo,
If like Deanna points out you are trying to import into locked columns that does have the problem of import wiping out the columns.
One get around is to not set the column values to auto update, but instead use code to update the values after the import with column class methods such as:
Worksheet wks = Project.ActiveLayer();
Column colObj(wks, 2);
colObj.ExecuteFormula();
// Note that you can also change the formula prgrammatically:
// colObj.SetFormula("col(B)*2");
Easwar
OriginLab