Hello,
Finding the relationship between 1 output and 5 inputs is nontrivial. Such a problem is much depending on the human brain, while the data analysis software can never be so smart to automatically determine the best surface fitting equation for you (but, who knows, maybe someday an incredible guy invents some algorithm to do this?).
So you may want to analyze your data first. Plotting the data in Origin does help you to find out the trend of output for different inputs, if you have enough data. You can also try the multiple regression on your data to see if "the output is linearly proportional to each input" is a good hypothesis (Linear is always the best model that we want to handle).
Some hints only, without knowing any detail of your data.
Leo
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