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tibiriandre

Burkina Faso
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Posted - 08/28/2009 :  05:59:09 AM  Show Profile  Edit Topic  Reply with Quote  View user's IP address  Delete Topic
Origin Ver. and Service Release (Select Help-->About Origin):
Operating System: Origin 8 SR6

Hi
Please, Can I get the derived parameter EC50 with SD or SEM when fitting replicate data and choosing concatenate fit?

larry_lan

China
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Posted - 08/31/2009 :  04:14:38 AM  Show Profile  Edit Reply  Reply with Quote  View user's IP address  Delete Reply
Hi:

No matter what kind of fit mode you use, we always output EC50 (supposed you use the DoseResponse fitting function), however, Origin doesn't output error for all derived parameters.

Larry
OriginLab Technical Services
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tibiriandre

Burkina Faso
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Posted - 09/04/2009 :  05:46:32 AM  Show Profile  Edit Reply  Reply with Quote  View user's IP address  Delete Reply
Thank you Larry!
I effectively got EC50 without SEM when using DoseResponse Logistic fitting fonction.
Can I suggest that in your future Services Releases you make EC50 be outputted with error (SEM and 95% CI)?
Thanks!!
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larry_lan

China
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Posted - 09/09/2009 :  05:12:32 AM  Show Profile  Edit Reply  Reply with Quote  View user's IP address  Delete Reply
Hi:

We are considering adding this in the next version. For now, maybe you can use Error Propagation to compute the error manually?

Take the built-in DoesResp fitting function as example. After fit, active the Fit Report worksheet, and you can run the following script to get the error:

// Get results to tree variable, tr.
getnlr tr;
// Compute the error of EC50.
e_EC50= 10^tr.LOGx0 * ln(10) * tr.e_LOGx0;
// Type the value of e_EC50.
e_EC50 = ;

Larry
Edited by - larry_lan on 09/09/2009 05:13:06 AM
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