I study the transport kinetic of the intestinal epithelium. My result quite similar to the others that they analyzed and fitted the results with Michaelis-Menten plus linear component.
I very young in the research and in this software. How can I analyzing and fitting the results with Michaelis-Menten plus linear component.
Basic equation ... Independent : S Dependent : V Parameters : Vmax, Km Definition : V = (Vmax * S) / (Km + S)
Not sure how you want to add linear component, but here is an example .. Independent : S Dependent : V Parameters : Vmax, Km, offset, scale Definition : V = offset + scale * ((Vmax * S) / (Km + S))
Follow the steps in the Help file to create the fitting function.
My results showed the curvilinear function (hyperbola+linear function) of transport rate of the intestinal epithelium and substrate concentration.
So, the intestinal epithelium transport this substrate via both active (Saturable or hyperbola function) and passive (Non-saturable/linear function) mechanisms.
Fitting with Michaelis-Menten plus linear componen
Posted - 10/02/2009 : 06:09:36 AM
