Hi Aldo,
Origin currently supports Simplex and Levenberg-Marquardt minimization, and does not offer the log-likelihood method.
It is not currently possible to replace the internal minimization methods used in the NLSF tool with your own routines (if that is what you were asking about).
If you have C code that does minimization using log-likelihood, you can try porting that to Origin C and then calling the OC function to perform the minimization, or create a DLL with external code that does minimization and call the DLL from Origin/OriginC.
Easwar OriginLab
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